Apolipoprotein E-Dependent Differences in Innate Immune Responses of Maturing Human Neuroepithelial Progenitor Cells Exposed to HIV-1

@article{Geffin2013ApolipoproteinED,
  title={Apolipoprotein E-Dependent Differences in Innate Immune Responses of Maturing Human Neuroepithelial Progenitor Cells Exposed to HIV-1},
  author={Rebeca Geffin and Ricardo G{\'o}mez Mart{\'i}nez and Roberto Perez and Biju Issac and Micheline McCarthy},
  journal={Journal of Neuroimmune Pharmacology},
  year={2013},
  volume={8},
  pages={1010-1026}
}
HIV enters the brain early during infection and induces a chronic inflammatory state that can result in neurological abnormalities in a subset of infected individuals. To investigate the effects of HIV exposure on neurogenesis and neuronal survival in the brain, we have used a model system consisting of human neuroepithelial progenitor (NEP) cells that undergo directed differentiation into astrocytes and neurons in vitro. Changes in gene expression in NEP cultures as a result of HIV exposure… CONTINUE READING
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