Apolipoprotein E 4 Allele Frequency and Age at Onset of Alzheimer ’ s Disease

  title={Apolipoprotein E 4 Allele Frequency and Age at Onset of Alzheimer ’ s Disease},
  author={Yvonne S. Davidson and Linda Gibbons and Antonia L Pritchard and Jayne Hardicre and Joanne Wren and Cheryl L Stopford and Camille L Julien and Jennifer Thompson and A. M. Payton and Stuart M. Pickering-Brown and Neil Pendleton and Michael Arthur Horan and Alistair Burns and Nitin B Purandare and Corinne L. Lendon and David Neary and Julie S. Snowden and David M A Mann},
The age distribution of the 4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE 4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE 4 allele was later than that in those EOAD cases without 4 allele, whereas in LOAD… CONTINUE READING
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