Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease.

@article{Wang2015ApolipoproteinE,
  title={Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease.},
  author={Xiao Pei Wang and Jinhui Wang and Yi He and Huiying Li and Huishu Yuan and Alan C. Evans and Xin Yu and Yong He and Huali Wang},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={45 3},
  pages={781-95}
}
The apolipoprotein E ε4 (APOE ε4) allele is a well-established genetic risk factor for Alzheimer's disease (AD). Numerous studies have suggested that the modulation of APOE ε4 affects cognition and brain structure and function in healthy populations, particularly in the hippocampus, a key area associated with AD pathology. However, the effect of APOE ε4 allele on cognitive performance, hippocampal structural morphology, and specifically on functional characteristics in patients with AD remains… CONTINUE READING

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