Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease: What Physicians Know, and What They Should Know

@inproceedings{Seshadri1995ApolipoproteinE,
  title={Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease: What Physicians Know, and What They Should Know},
  author={Sudha Seshadri and David A. Drachman and Carol F Lippa},
  year={1995}
}
Background: Published studies now show a clear association between Alzheimer's disease (AD) and the apolipoprotein E e4 allele (APOE*e4). The clinical value of this information to estimate a healthy individual's lifetime risk of AD has not been well delineated. Physicians dealing with AD may not know either the lifetime risk of developing AD or the effect of theAPOEgenotype on this risk. Because the lifetime risk of AD depends in part on life expectancy, and available figures onAPOEare not… CONTINUE READING

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