Apolipoprotein E Â 4 Allele Is a Risk Factor for Alzheimer ’ s Disease : The Central Region of Portugal ( Coimbra ) as a Case Study

Alzheimer’s disease (AD), an age-associated neurodegenerative disorder, is characterized by a progressive decline of the cognitive functions, in particular a loss of memory, learning and attention, and it does not have a simple etiology. Most of the cases are sporadic and the factors involved are unknown. A very small percentage of cases are hereditary and… (More)