Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.

@article{Mahley1988ApolipoproteinEC,
  title={Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.},
  author={Robert W. Mahley},
  journal={Science},
  year={1988},
  volume={240 4852},
  pages={622-30}
}
Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body. A mutant form of apolipoprotein E that is defective in binding to low density lipoprotein receptors is associated with familial type III hyperlipoproteinemia, a genetic disorder characterized by elevated plasma cholesterol levels and accelerated coronary… CONTINUE READING