Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.

  title={Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.},
  author={Na Zhao and Chia-Chen Liu and Wenhui Qiao and Guojun Bu},
  journal={Biological psychiatry},
  volume={83 4},
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). ApoE4 contributes to AD pathogenesis by modulating multiple pathways, including but not limited… CONTINUE READING



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