Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding.

@article{MacPhee2000ApolipoproteinCA,
  title={Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding.},
  author={Cait E. MacPhee and Danny M Hatters and William H. Sawyer and Geoffrey J. Howlett},
  journal={Biochemistry},
  year={2000},
  volume={39 12},
  pages={3433-40}
}
Apolipoprotein C-II (apoC-II) is an exchangeable plasma apolipoprotein and an endogenous activator of lipoprotein lipase (LpL). Genetic deficiencies of apoC-II and overexpression of apoC-II in transgenic mice are both associated with severe hyperlipidemia, indicating a complex role for apoC-II in the regulation of blood lipid levels. ApoC-II exerts no effect on the activity of LpL for soluble substrates, suggesting that activation occurs via the formation of a lipid-bound complex. We have… CONTINUE READING