Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes.

@article{Asciutto2016ApolipoproteinBA,
  title={Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes.},
  author={Giuseppe Asciutto and Maria Wigren and Gunilla Nordin Fredrikson and Ingrid Yao Mattisson and Caitr{\'i}ona Gr{\"o}nberg and Ragnar Alm and Harry Bj{\"o}rkbacka and Nuno Dias and Andreas Edsfeldt and I. Gonçalves and Jan Nilsson},
  journal={Stroke},
  year={2016},
  volume={47 4},
  pages={
          1140-3
        }
}
BACKGROUND AND PURPOSE Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease. METHODS Native and MDA-p45 IgG levels were analyzed by ELISA in 349 carotid endarterectomy patients. In a subcohort of 195 subjects, endarterectomy samples were analyzed by… CONTINUE READING
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