Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.

@article{Pennacchio2003ApolipoproteinAA,
  title={Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.},
  author={Len A. Pennacchio and Edward M. Rubin},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 4},
  pages={529-34}
}
Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affected plasma triglyceride concentrations. Mice that overexpressed human APOA5 displayed significantly reduced triglycerides, whereas mice that lacked apoa5 had a large increase in this lipid parameter. Studies… CONTINUE READING

From This Paper

Topics from this paper.
51 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…