Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine.


Apolipoprotein A-V is an important determinant of plasma triglyceride level in both humans and mice. This study showed the physiological impact of apoA-V on insulin secretion in rat pancreatic beta-cells (INS-1 cells). In order to precise the mechanism of action, binding experiments coupled to mass spectrometry were performed to identify a potential… (More)
DOI: 10.1159/000257484


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