Apolipoprotein A-I mimetic peptides.

  title={Apolipoprotein A-I mimetic peptides.},
  author={Mohamad Navab and G. M. Anantharamaiah and Srinivasa T. Reddy and Susan Y Hama and Greg P Hough and Victor R. Grijalva and Nicholas Yu and Benjamin J. Ansell and Geeta Datta and David W. Garber and Alan M. Fogelman},
  journal={Current atherosclerosis reports},
  volume={11 1},
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F. When given orally to mice and monkeys, D-4F caused the formation of pre-beta high-density lipoprotein (HDL), improved HDL-mediated cholesterol efflux, reduced lipoprotein lipid hydroperoxides… CONTINUE READING