Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.

  title={Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.},
  author={Salil Sharma and Soban Umar and Francois Potus and Andrea Iorga and Gabriel H Wong and David Meriwether and Sandra Breuils-Bonnet and Denise Mai and Kaveh Daniel Navab and David L. Ross and Mohamad Navab and Steeve Provencher and Alan M. Fogelman and S{\'e}bastien Bonnet and Srinivasa T. Reddy and Mansoureh Eghbali},
  volume={130 9},
BACKGROUND Pulmonary arterial hypertension is a chronic lung disease associated with severe pulmonary vascular changes. A pathogenic role of oxidized lipids such as hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids is well established in vascular disease. Apolipoprotein A-I mimetic peptides, including 4F, have been reported to reduce levels of these oxidized lipids and improve vascular disease. However, the role of oxidized lipids in the progression of pulmonary arterial hypertension and… CONTINUE READING
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