Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI

@article{Lorenzi2007ApolipoproteinAB,
  title={Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI},
  author={Iris Lorenzi and Arnold von Eckardstein and Clara Cavelier and Silvija Radosavljevic and Lucia Rohrer},
  journal={Journal of Molecular Medicine},
  year={2007},
  volume={86},
  pages={171-183}
}
Accumulation of lipid-loaded macrophages (foam cells) within the vessel wall is an early hallmark of atherosclerosis. High-density lipoproteins (HDL) and apolipoprotein A-I (apoA-I) can efficiently promote cholesterol efflux from macrophages. Therefore, the interaction of HDL and apoA-I with macrophages appears to be important in the initial steps of reverse cholesterol transport, i.e. the transport of excess cholesterol from foam cells to the liver. However, although several cellular apoA-I… CONTINUE READING

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References

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Current understanding of the metabolism and biological actions of HDL.

Current opinion in clinical nutrition and metabolic care • 2005
View 1 Excerpt

Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux

BF Asztalos, Llera-MoyaM de la, +3 authors GH Rothblat
J Lipid Res • 2005
View 1 Excerpt

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