Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.

  title={Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.},
  author={J R Nofer and Alan T Remaley and Renata Feuerborn and Iza Wolinnska and Thomas Engel and Arnold von Eckardstein and G. A\ssmann},
  journal={Journal of lipid research},
  volume={47 4},
It has been suggested that the signal transduction initiated by apolipoprotein A-I (apoA-I) activates key proteins involved in cholesterol efflux. ABCA1 serves as a binding partner for apoA-I, but its participation in apoA-I-induced signaling remains uncertain. We show that the exposure of human fibroblasts to ABCA1 ligands (apolipoproteins and amphipathic helical peptides) results in the generation of intracellular signals, including activation of the small G-protein Cdc42, protein kinases… CONTINUE READING