Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis

@inproceedings{Saleheen2017ApolipoproteinaIS,
  title={Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis},
  author={Danish Saleheen and Philip C. Haycock and Wei Zhou and A Muzib Hassanal Rasheed and Adam Taleb and Atif Imran and Shahid Abbas and Faisal Majeed and Saba Akhtar and Nadeem Qamar and Khan Shah Zaman and Zia Yaqoob and Tahir Saghir and Syed Nadeem Hasan Rizvi and Anis Memon and Nadeem Hayyat Mallick and Mohammad G Ishaq and Syed Zahed Rasheed and Fazal-ur-Rehman Memon and Khalid Mahmood and Naveeduddin Ahmed and Philippe M. Frossard and Sotirios Tsimikas and Joseph L. Witztum and Santica M. Marcovina and Manjinder S. Sandhu and Daniel J. Rader and John Danesh},
  booktitle={The lancet. Diabetes & endocrinology},
  year={2017}
}
BACKGROUND The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and circulating lipoprotein(a) concentration, to coronary heart disease. METHODS In this mendelian randomisation study, we measured lipoprotein(a) concentration and determined apolipoprotein(a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene… CONTINUE READING
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