Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the rat.

@article{Hu2006ApocyninBN,
  title={Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the rat.},
  author={Lexian Hu and Yi Irvette Zhang and Pek Siew Lim and Yuchun Miao and Chrismin C. Tan and Katja U S McKenzie and Christopher G. Schyvens and Judith Ann Whitworth},
  journal={American journal of hypertension},
  year={2006},
  volume={19 4},
  pages={413-8}
}
BACKGROUND Dexamethasone (Dex)-hypertension in rats is associated with increased oxidative stress. We investigated effects of the NAD(P)H oxidase inhibitor apocynin and the nitric oxide (NO) precursor L-arginine on Dex-hypertension to determine the relative roles of NAD(P)H oxidase and uncoupling in the reactive oxygen species (ROS) generation and hypertension. METHODS Male Sprague-Dawley rats (n = 10/group) received Dex (20 microg/kg/day subcutaneously) or saline (vehicle) for 14 days. In a… CONTINUE READING

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