Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor.

@article{Sams2002ApocalmodulinAC,
  title={Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor.},
  author={Montserrat Sams{\'o} and Terence Wagenknecht},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 2},
  pages={1349-53}
}
Calmodulin (CaM) binds to the ryanodine receptor/calcium release channel of skeletal muscle (RyR1), both in the absence and presence of Ca(2+), and regulates the activity of the channel activity by activating and inhibiting it, respectively. Using cryo-electron microscopy and three-dimensional reconstruction, we found that one apoCaM binds per RyR1 subunit along the sides of the cytoplasmic assembly of the receptor. This location is distinct from but close to the location found for Ca(2+)-CaM… CONTINUE READING

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