Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

Abstract

Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor for development of cardiovascular disease. Animal models… (More)
DOI: 10.1242/dmm.019836

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Cite this paper

@inproceedings{Liu2015Apoc2LZ, title={Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia}, author={Cheng Chih Liu and Keith P. Gates and Longhou Fang and Marcelo J Amar and Dina A. Schneider and Honglian Geng and Wei Huang and Jungsu Kim and Jennifer W Pattison and Jian Feng Zhang and Joseph L. Witztum and Alan T Remaley and P. Duc Si Dong and Yury I. Miller}, booktitle={Disease models & mechanisms}, year={2015} }