ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.

@article{Bandaru2009ApoE4DS,
  title={ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.},
  author={Veera Venkata Ratnam Bandaru and Juan Troncoso and David Wheeler and Olga Pletnikova and Jessica Wang and Kathy Conant and Norman J Haughey},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 4},
  pages={591-9}
}
The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent models, there has not been a direct quantification of sphingomyelin or sterol levels in the brains of patients with different forms of ApoE. We measured the sphingolipid and sterol content of… CONTINUE READING

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