ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.

@article{Mulik2012ApoE3MP,
  title={ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.},
  author={R. S. Mulik and Jukka M{\"o}nkk{\"o}nen and Risto O Juvonen and Kakasaheb Ramoo Mahadik and Anant Paradkar},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={437 1-2},
  pages={29-41}
}
Curcumin, a natural phytoconstituent, is known to be therapeutically effective in the treatment of various cancers such as, breast cancer, lung cancer, pancreatic cancer, brain cancer, etc. However, low bioavailability and photodegradation of curcumin hampers its overall therapeutic efficacy. Anionic polymerization method was employed for the preparation of apolipoprotein-E3 mediated curcumin loaded poly(butyl)cyanoacrylate nanoparticles (ApoE3-C-PBCA) and characterized for size, zeta potential… CONTINUE READING

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