ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease

  title={ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease},
  author={Amandine Mouchard and Marie-Charlotte Boutonnet and Claire Mazzocco and Nathalie Biendon and Nathalie Macrez},
  booktitle={Scientific Reports},
Identification of endogenous pathological amyloid β peptides (Aβ) forms in the brains of patients with Alzheimer’s disease (AD) is still unclear. In healthy brain, Aβ can associate with Apolipoprotein E (ApoE) which is involved in its metabolism and clearance. In the brain of patients with AD, ApoE is cleaved and produces ApoE fragments. We studied the forms of Aβ and their interaction with the ApoE fragments in post-mortem brains from control and AD patients by western blots and co… CONTINUE READING


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