ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

@article{Palinski1994ApoEdeficientMA,
  title={ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.},
  author={Wulf Palinski and V A Ord and Andrew S. Plump and Jan L. Breslow and Daniel Steinberg and Joseph L. Witztum},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 4},
  pages={605-16}
}
Apolipoprotein (apo) E-deficient transgenic mice develop marked hyperlipidemia and progressive atherosclerotic lesions. To explore whether oxidative modification of lipoproteins is involved in atherogenesis in this murine model, we performed extensive immunocytochemical studies. Atherosclerotic lesions ranging from early fatty streaks to very advanced plaques were examined from the aortic valve region and the thoracic and abdominal aorta. Using guinea pig antisera against malondialdehyde (MDA… CONTINUE READING
168 Citations
48 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 168 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Role of modified lipoproteins in atherosclerosis

  • W. Palinslti
  • Robenek H, Severs NJ, eds. Cell Interactions in…
  • 1992
Highly Influential
9 Excerpts

Immunoglobulins extracted from atherosclerotic lesions recognize epitopes of oxidized low density lipoproteins

  • S YlS-Herttuala, W Palinski, S Picard, S Butler, D Steinberg, JL. Witztum
  • Arterioscler Thromb
  • 1994
8 Excerpts

Similar Papers

Loading similar papers…