ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain

  title={ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain},
  author={Uwe Beffert and Farnas Nematollah Farsian and Irene Masiulis and Robert Hammer and Sung Ok Yoon and Klaus M. Giehl and Joachim Herz},
  journal={Current Biology},
A central pathogenic feature of neurodegenerative diseases and neurotrauma is the death of neurons. A mechanistic understanding of the factors and conditions that induce the dysfunction and death of neurons is essential for devising effective treatment strategies against neuronal loss after trauma or during aging. Because Apolipoprotein E (ApoE) is a major risk factor for several neurodegenerative diseases, including Alzheimer's disease , a direct or indirect role of ApoE receptors in the… CONTINUE READING


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