ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population

@article{Juhsz2005ApoEP,
  title={ApoE −491A/T Promoter Polymorphism is not an Independent Risk Factor, but Associated with the ε4 Allele in Hungarian Alzheimer’s Dementia Population},
  author={A. G{\'e}mesn{\'e} Juh{\'a}sz and Andr{\'a}s Palot{\'a}s and Zolt{\'a}n Janka and {\'A}gnes Riman{\'o}czy and Mikl{\'o}s Palot{\'a}s and Nikoletta B{\'o}di and Krisztina Boda and Marianna Zana and G{\'a}bor Vincze and J{\'a}nos K{\'a}lm{\'a}n},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={591-596}
}
Apolipoprotein E gene (Apoε) has three common alleles (ε2, ε3, and ε4), of which ε4 has been shown to be associated with an increased risk for Alzheimer’s disease (AD). Possible additional genetic factors, like the −491A variant of ApoE promoter may modify the development of AD, independently of the ApoE allele status. The objective of this study was to investigate whether A/T allelic polymorphism at site−491 of the ApoE promoter is associated with AD in a Hungarian population. The genomic DNA… CONTINUE READING

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