ApoB-100 Has a Pentapartite Structure Composed of Three Amphipathic ar-Helical Domains Alternating With Two Amphipathic / 3-Strand Domains Detection by the Computer Program LOCATE *


Due to the great length of apolipoprotein (apo) B-100, the localization of lipid-associating domains in this protein has been difficult. To address this question, we developed a computer program called LOCATE that searches amino acid sequences to identify potential amphipathic a-helixes and /3-strands by using sets of rules for helix and strand termination… (More)

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