ApoA-I Facilitates ABCA1 Recycle/Accumulation to Cell Surface by Inhibiting Its Intracellular Degradation and Increases HDL Generation

@article{Lu2008ApoAIFA,
  title={ApoA-I Facilitates ABCA1 Recycle/Accumulation to Cell Surface by Inhibiting Its Intracellular Degradation and Increases HDL Generation},
  author={Rui Lu and R. Arakawa and Chisato Ito-Osumi and N. Iwamoto and S. Yokoyama},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2008},
  volume={28},
  pages={1820-1824}
}
Objective—Calpain-mediated proteolysis is one of the major regulatory factors for activity of ATP-binding cassette transporter (ABC) A1. Helical apolipoproteins protect ABCA1 against this degradation and increase generation of HDL. We investigated the mechanism for this reaction focusing on roles of endocytotic internalization of ABCA1. Methods and Results—Surface ABCA1 was labeled with biotin and traced for its internalization and degradation. ABCA1 in the cell surface was internalized within… Expand
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