Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice.

Abstract

Lycopene has been shown to be beneficial in protecting against high-fat diet-induced fatty liver. The recent demonstration that lycopene can be converted by carotene 9',10'-oxygenase into a biologically active metabolite, ALA, led us to propose that the function of lycopene can be mediated by ALA. In the present study, male ob/ob mice were fed a liquid high… (More)
DOI: 10.3945/jn.111.150052

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Cite this paper

@article{Chung2012Apo10lycopenoicAA, title={Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice.}, author={Jayong Chung and Kyeongok Koo and Fuzhi Lian and Kang - Quan Hu and H. Ernst and Xiang-Dong Wang}, journal={The Journal of nutrition}, year={2012}, volume={142 3}, pages={405-10} }