Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides.

  title={Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides.},
  author={Mireille A. Sch{\"a}fer and Marina R. Picciotto and T Kreiner and R R Kaldany and R A Taussig and Richard H. Scheller},
  volume={41 2},
The neuroactive peptide Phe-Met-Arg-Phe-NH2 (FMRF-amide) has a variety of effects on both mammalian and invertebrate tissues; moreover, FMRFamide-like immunoreactivity is found throughout the animal kingdom. Here we describe the isolation and characterization of a cDNA clone from an Aplysia abdominal ganglion cDNA library that encodes a precursor protein that may give rise to as many as 19 individual FMRFamide peptides. Nearly all of the FMRF sequences are flanked on the amino terminus by Lys… CONTINUE READING