• DOI:10.1016/j.cell.2010.01.008
Corpus ID: 14305206

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

@article{Si2010AplysiaCC,
  title={Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation},
  author={Kausik Si and Yun-Beom Choi and Erica White-Grindley and A. Majumdar and E. Kandel},
  journal={Cell},
  year={2010},
  volume={140},
  pages={421-435}
}

Kausik Si, Yun-Beom Choi, +2 authors E. Kandel

Published 2010

Biology, Medicine

Cell

Prions are proteins that can assume at least two distinct conformational states, one of which is dominant and self-perpetuating. Previously we found that a translation regulator CPEB from Aplysia, ApCPEB, that stabilizes activity-dependent changes in synaptic efficacy can display prion-like properties in yeast. Here we find that, when exogenously expressed in sensory neurons, ApCPEB can form an amyloidogenic self-sustaining multimer, consistent with it being a prion-like protein. In addition… CONTINUE READING

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