Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

  title={Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation},
  author={Kausik Si and Yun-Beom Choi and Erica White-Grindley and Amitabha Majumdar and Eric R. Kandel},

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Characterization of prion-like conformational changes of the neuronal isoform of Aplysia CPEB

Biophysical methods are used to demonstrate that Aplysia CPEB, like other prions, undergoes a conformational switch from soluble α-helix–rich oligomer to β-sheet–rich fiber in vitro, providing physiological evidence that the prion-like properties of AplySia C PEB might explain the self-sustained, continuous molecular turnover at the synapse.

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A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties

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