Aplotaxene blocks T cell activation by modulation of protein kinase C-θ-dependent pathway.

@article{Na2013AplotaxeneBT,
  title={Aplotaxene blocks T cell activation by modulation of protein kinase C-θ-dependent pathway.},
  author={Bo-Ra Na and Hye-Ran Kim and Min-Sung Kwon and Hyun-Su Lee and Indre Piragyte and Eun-Ju Choi and Hyun-Kyu Choi and Weon-Cheol Han and Seung-Ho Lee and Chang-Duk Jun},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={62},
  pages={
          23-31
        }
}
  • Bo-Ra Na, Hye-Ran Kim, +7 authors Chang-Duk Jun
  • Published in
    Food and chemical toxicology : an international…
    2013
  • DOI:10.1016/j.fct.2013.08.016
Aplotaxene, (8Z, 11Z, 14Z)-heptadeca-1, 8, 11, 14-tetraene, is one of the major components of essential oil obtained from Inula helenium root, which is used in Oriental medicine. However, the effects of aplotaxene on immunity have not been investigated. Here, we show that aplotaxene inhibits T cell activation in terms of IL-2 and CD69 expression. Aplotaxene, at a concentration that optimally inhibits IL-2 production, has little effect on apoptotic or necrotic cell death, suggesting that… CONTINUE READING

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