Aplicabilidade da extrapolação alométrica em protocolos terapêuticos para animais selvagens

@article{Freitas2013AplicabilidadeDE,
  title={Aplicabilidade da extrapolaç{\~a}o alom{\'e}trica em protocolos terap{\^e}uticos para animais selvagens},
  author={Gabrielle Coelho Freitas and Adriano Bonfim Carregaro},
  journal={Ciencia Rural},
  year={2013},
  volume={43},
  pages={297-304}
}
In Veterinary Medicine, the empirical extrapolation of protocols indicated for domestic animals is a common practice, which can lead to a failure by ignoring the particularities of each species. The use of scales that allows the use of known doses in domestic animals to calculate the doses for wild species becomes useful. Allometric scales considers the metabolic rate of each species, providing a better comparison between animals of different masses and taxonomic groups. Allometry can be used… 
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References

SHOWING 1-10 OF 41 REFERENCES
Concepts and Issues with Interspecies Scaling in Zoological Pharmacology
  • R. P. Hunter, R. Isaza
  • Biology, Medicine
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • 2008
TLDR
Three methods for dosage selection are discussed and compared and allometric scaling of pharmacokinetic parameters is compared to enhance the ability to estimate therapeutic dosages for nondomestic species.
Contenção farmacológica do gato-do-mato-pequeno, Leopardus tigrinus, para colheita de sêmen, pela associação de tiletamina zolazepam e xilazina
TLDR
The three tested protocols showed to be safe and effective to produce analgesia and anesthesia in L. tigrinus during semen collection by electroejaculation.
Extrapolation of pharmacological and toxicological data based on metabolic weight.
  • V. As
  • Biology, Environmental Science
  • 1989
TLDR
The approaches suggested in the discussion for a solution to the problem may help expanding possibilities for extrapolation of pharmacological and toxicological data from laboratory animal to those relevant to man and other mammalian species.
Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species.
TLDR
Results of this study show that interspecies scaling is applicable to certain veterinary drugs and could have important consequences in terms of avoiding the use of dose-titration studies in Phase I of drug development, for drugs that are experimentally 'well behaved.
Influência da temperatura corporal de cascavéis (Crotalus durissus) submetidas à anestesia com cetamina
TLDR
It was evident that body temperature exerts intense influence on the recovery time on rattlesnakes anesthetized with ketamine.
Metabolic scaling of antibiotics in reptiles: Basis and limitations
TLDR
Until more scientifically derived information is available for demonstrating the accuracy of metabolic scaling of antibiotics in reptiles, the clinician will need to understand the limitations of this approach.
Interspecies allometric scaling. Part I: prediction of clearance in large animals.
TLDR
There is a much larger risk of inaccuracies in the clearance estimates in large animal species when compared with that observed for humans, and mechanisms for reducing the risk of extrapolation errors are considered.
Interspecies allometric scaling: prediction of clearance in large animal species: part II: mathematical considerations.
TLDR
The factors influencing the accuracy of the clearance estimates are examined from the perspective of the relationship between prediction error and such variables as the distribution of body weight values used in the regression analysis, the influence of a particular observation on the clearance estimate, and the 'goodness of fit' of the regression line.
Mixed effects modeling of the disposition of gentamicin across domestic animal species.
TLDR
The pharmacokinetic characteristics of drugs such as gentamicin, can be predicted across species using a population pharmacokinetics modeling approach, and that clinical features that affect species in a similar manner can be also explored in this fashion.
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