Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.

@article{Fohlmeister1985AplasticAA,
  title={Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.},
  author={Ingrid Fohlmeister and Robert Fischer and Bruno M{\"o}dder and Manfred Rister and Hans Eckart Schaefer},
  journal={Journal of clinical pathology},
  year={1985},
  volume={38 11},
  pages={1218-24}
}
In a retrospective study of 111 patients with aplastic anaemia iliac crest biopsies were evaluated for the presence of morphological features statistically related to the evolution of the disease. Prognostic variables for a transition to acute non-lymphatic leukaemia were: cellular atypias of the three haemopoietic lineages, as observed in the myelodysplastic syndrome, and especially "micromegakaryocytes"; high numbers or irregular distribution of megakaryocytes, or both; and (slight) marrow… CONTINUE READING
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