Apixaban metabolism and pharmacokinetics after oral administration to humans.

@article{Raghavan2009ApixabanMA,
  title={Apixaban metabolism and pharmacokinetics after oral administration to humans.},
  author={Nirmala Raghavan and Charles E. Frost and Zhigang Yu and Kan He and Haiying Zhang and W Griffith Humphreys and Donald J P Pinto and Shiangyuan Chen and Samuel J. Bonacorsi and Pancras C. Wong and Donglu Zhang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 1},
  pages={74-81}
}
The metabolism and disposition of [(14)C]apixaban, an orally bioavailable, highly selective, and direct acting/reversible factor Xa inhibitor, was investigated in 10 healthy male subjects without (group 1, n=6) and with bile collection (group 2, n=4) after a single 20-mg oral dose. Urine, blood, and feces samples were collected from all subjects. Bile samples were also collected for 3 to 8 h after dosing from group 2 subjects. There were no serious adverse events or discontinuations due to… CONTINUE READING
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