Apixaban: an oral direct factor-xa inhibitor.

  title={Apixaban: an oral direct factor-xa inhibitor.},
  author={David Jim{\'e}nez and Roger D. Yusen and Eduardo Ramacciotti},
  journal={Advances in therapy},
  volume={29 3},
Apixaban is a highly selective, reversible, direct factor Xa inhibitor that inhibits both free factor Xa and prothrombinase activity, and clot-bound factor Xa activity. A predictable pharmacokinetic profile, multiple pathways of elimination, an improved bleeding profile relative to warfarin with a lack of other significant adverse events, and no need for routine anticoagulation monitoring make apixaban appealing. Apixaban is currently approved for venous thromboembolism (VTE) prophylaxis in… CONTINUE READING


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