Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells.

@article{Vargo2006ApigenininducedapoptosisIM,
  title={Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells.},
  author={Melissa A Vargo and Oliver H. Voss and Frantisek Poustka and Arturo J. Cardounel and Erich Grotewold and Andrea I. Doseff},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 6},
  pages={681-92}
}
Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. In the present study, the treatment of different cell lines with apigenin resulted in selective antiproliferative and apoptotic effect in monocytic and lymphocytic leukemias. Apigenin-induced-apoptosis was mediated by the activation of caspase-9 and caspase-3. Apigenin was found intracellularly and localized to the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…