Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.

@article{Shin2009ApigenininducedAI,
  title={Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.},
  author={Gu-Choul Shin and Changyoun Kim and Jong-Min Lee and Wang-Sik Cho and Sang-gyu Lee and Mini Jeong and Jaewook Cho and Kyungho Lee},
  journal={Chemico-biological interactions},
  year={2009},
  volume={182 1},
  pages={
          29-36
        }
}
Fibroblast-like synovial cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA), as these cells are involved in inflammation and joint destruction. Apigenin, a dietary plant-flavonoid, is known to have many functions in animal cells including anti-proliferative and anticancer activities, but its role in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) has not been reported. In this study, we investigated the roles of apigenin in RA-FLSs. The survival rate… CONTINUE READING

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