Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria.

@article{Das2012ApigenininducedAI,
  title={Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria.},
  author={Sreemanti Das and Jayeeta Das and Asmita Samadder and Naoual Boujedaini and Anisur Rahman Khuda-Bukhsh},
  journal={Experimental biology and medicine},
  year={2012},
  volume={237 12},
  pages={1433-48}
}
We isolated apigenin (5,7,4'-trihydroxy flavone) from ethanolic extract of Lycopodium clavatum (LC) used as a homeopathic mother tincture for treatment of various diseases. We assessed the anticancer potentials of the compound using human malignant melanoma cell line A375 and a lung carcinoma cell line A549 and focussed on its putative molecular mechanism of action on apoptosis induction. We examined the cytotoxicity of apigenin in both cancer cells and normal peripheral blood mononuclear cells… CONTINUE READING

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