Apigenin and Hesperidin Downregulate DNA Repair Genes in MCF-7 Breast Cancer Cells and Augment Doxorubicin Toxicity

@article{KorgaPlewko2020ApigeninAH,
  title={Apigenin and Hesperidin Downregulate DNA Repair Genes in MCF-7 Breast Cancer Cells and Augment Doxorubicin Toxicity},
  author={Agnieszka Korga-Plewko and Monika Michalczyk and Grzegorz Adamczuk and E. Humeniuk and Marta Ostrowska-Lesko and A. J{\'o}zefczyk and Magdalena Iwan and M. W{\'o}jcik and J. Dudka},
  journal={Molecules},
  year={2020},
  volume={25}
}
A number of studies have confirmed anti-tumor activity of flavonoids and their ability to enhance the effectiveness of classical anticancer drugs. The mechanism of this phenomenon is difficult to explain because of the ambivalent nature of these compounds. Many therapeutic properties of these compounds are attributed to their antioxidant activity; however, it is known that they can act as oxidants. The aim of this study was to assess the influence of apigenin and hesperidin on MCF-7 breast… Expand

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