Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes.

@article{Begum2012ApigeninAG,
  title={Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes.},
  author={Naziya Begum and Nagarajan Rajendra Prasad and G. Kanimozhi and Annie Q Hasan},
  journal={Mutation research},
  year={2012},
  volume={747 1},
  pages={71-6}
}
The aim of the present study was to assess the protective effect of apigenin, a dietary flavone, against cytogenetic alterations in human peripheral blood lymphocytes (HPBL) induced by Cobalt-60 radiation (3Gy). Results of MTT [3-(4, 5-dimethyl-2-thiaozolyl)-2,5-diphenyl-2H tetrazolium bromide] assay revealed that 37.2μM of apigenin was found to be non-toxic in HPBL. At this dose (37.2μM) of apigenin, the LD(50) radiation dose of HPBL increased from 2.9Gy to 3.4Gy, which resulted in a DMF of 1… CONTINUE READING

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