Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo.

@article{Engelmann2002ApigeninstrongCA,
  title={Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo.},
  author={Carsten Engelmann and Emmanuel Blot and Yves Panis and Sabine Bauer and V{\'e}ronique Trochon and Helena Juliana Nagy and Hua Lu and Claudine Soria},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2002},
  volume={9 6},
  pages={
          489-95
        }
}
The cancer chemopreventive agent apigenin also has strong cytostatic and anti-angiogenic effects in vitro. We now investigated its efficacy against experimental Lewis lung carcinomas (LLC), C-6 gliomas and DHDK 12 colonic cancers in vivo. Tumour bearing mice received 50 mg/kg/day apigenin in three different galenical formulations during 12 days in 8-hourly intervals. Only weak effects of apigenin on the size and the number of new tumour blood vessels of both established and newly transplanted… CONTINUE READING

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