Apidaecin-type peptide antibiotics function through a non-poreforming mechanism involving stereospecificity.

@article{Casteels1994ApidaecintypePA,
  title={Apidaecin-type peptide antibiotics function through a non-poreforming mechanism involving stereospecificity.},
  author={Peter Casteels and Paul Tempst},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 1},
  pages={339-45}
}
Insect resistance to bacterial infections is dependent on the production of specialized defense peptides. We report here that lethal activities of apidaecin, a small peptide from honeybees, cannot possibly be the result of a conventional 'lytic' mechanism. Evidence includes the complete lack of membrane permeabilization, at concentrations that exceed lethal… CONTINUE READING