Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.

@article{Ramakrishnan2012ApicoplastAE,
  title={Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.},
  author={Srinivasan Ramakrishnan and Melissa D. Docampo and James I. MacRae and François M. Pujol and Carrie F. Brooks and Giel G van Dooren and Jukka Kalervo Hiltunen and Alexander J. Kastaniotis and Malcolm J. McConville and Boris Striepen},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 7},
  pages={4957-71}
}
Apicomplexan parasites are responsible for high impact human diseases such as malaria, toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent on both de novo lipid biosynthesis as well as the uptake of host lipids for biogenesis of parasite membranes. Genome annotations and biochemical studies indicate that apicomplexan… CONTINUE READING