Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum

@article{Gnther2007ApicoplastLA,
  title={Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum},
  author={Svenja G{\"u}nther and Lynsey J M Wallace and E M Patzewitz and Paul J. McMillan and Janet Storm and Carsten Wrenger and Ryan Bissett and Terry K. Smith and Sylke M{\"u}ller},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={961 - 1004}
}
Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways. Biosynthesis of LA exclusively occurs in the apicoplast, comprising octanoyl-[acyl carrier protein]: protein N-octanoyltransferase (LipB) and LA synthase. Salvage of LA is mitochondrial and scavenged LA is ligated to the KADHs by LA protein ligase 1 (LplA1). Both pathways are entirely… CONTINUE READING