Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

@article{Chandramohanadas2009ApicomplexanPC,
  title={Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.},
  author={Rajesh Chandramohanadas and Paul H. Davis and Daniel P. Beiting and Michael B Harbut and Claire Darling and Geetha Velmourougane and Ming Yeh Lee and Peter A. Greer and David S. Roos and Doron C. Greenbaum},
  journal={Science},
  year={2009},
  volume={324 5928},
  pages={794-7}
}
Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii (the causative agents of malaria and toxoplasmosis, respectively), are responsible for considerable morbidity and mortality worldwide. These pathogenic protozoa replicate within an intracellular vacuole inside of infected host cells, from which they must escape to initiate a new lytic cycle. By integrating cell biological, pharmacological, and genetic approaches, we provide evidence that both Plasmodium and Toxoplasma… CONTINUE READING