Apicobasal polarity and its role in cancer progression

@inproceedings{Lo2012ApicobasalPA,
  title={Apicobasal polarity and its role in cancer progression},
  author={Priscilla J.K.P. Lo and Hannah Hawrot and Marios Georgiou},
  booktitle={Biomolecular concepts},
  year={2012}
}
Abstract Appropriate establishment and maintenance of cell polarity is essential for normal development and homeostasis. The vast majority of human cancers originate from epithelial tissues and tumour cell invasion and metastasis are the major cause of mortality in human cancers. Invading cells demonstrate loss of cell polarity, loss of epithelial cell-cell adhesions and tissue disorganisation. We examine the growing evidence linking loss of apicobasal polarity with tumour progression. 
ignalling networks in focus hoGTPase signalling at epithelial tight junctions : Bridging the GAP etween polarity and cancer
The establishment and maintenance of epithelial polarity must be correctly controlled for normal development and homeostasis. Tight junctions (TJ) in vertebrates define apical and basolateralExpand
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Using the genetic amenability of Drosophila melanogaster, a detailed systematic loss-of-function analysis was carried out to identify conserved genes that enhance or suppress epithelial tumor progression and the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved invasion suppressors. Expand
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RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer
  • C. Zihni, S. Terry
  • Biology, Medicine
  • The international journal of biochemistry & cell biology
  • 2015
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It is determined that the expression, localization or stability of a variety of these adaptor proteins is altered in various cancers, potentially representing an important mechanistic link between loss of polarity and cancer. Expand
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The relationships between the Rho family GTPases and epithelial AB polarization events are reviewed, focusing on the 3 best-characterized members: Rho, Rac and Cdc42. Expand
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