ApicoAP: The First Computational Model for Identifying Apicoplast-Targeted Proteins in Multiple Species of Apicomplexa

@inproceedings{Cilingir2012ApicoAPTF,
  title={ApicoAP: The First Computational Model for Identifying Apicoplast-Targeted Proteins in Multiple Species of Apicomplexa},
  author={Gokcen Cilingir and Shira L. Broschat and Audrey O. T. Lau},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Most of the parasites of the phylum Apicomplexa contain a relict prokaryotic-derived plastid called the apicoplast. This organelle is important not only for the survival of the parasite, but its unique properties make it an ideal drug target. The majority of apicoplast-associated proteins are nuclear encoded and targeted post-translationally to the organellar lumen via a bipartite signaling mechanism that requires an N-terminal signal and transit peptide (TP). Attempts to define a… CONTINUE READING

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