Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters

@article{Martel2000ApicalUO,
  title={Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters},
  author={F{\~a}tima Martel and Dirk Gr{\"u}ndemann and Conceiç{\~a}o Calhau and Edgar Sch{\"o}mig},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2000},
  volume={363},
  pages={40-49}
}
The aim of this work was to characterise the intestinal absorption of organic cations, by testing the possibility of involvement of known members of the amphiphilic solute facilitator (ASF) family in this process. For that purpose, the characteristics of the uptake of 1-methyl-4-phenylpyridinium, a model organic cation, at the brush-border membrane of Caco-2 cells were compared with those of the extraneuronal monoamine transporter (EMT)-mediated transport. Uptake of [3H]MPP+ by Caco-2 and… CONTINUE READING

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