Apical secretion of hepatitis B surface antigen from transfected Madin-Darby canine kidney cells.

@article{Gonzlez1993ApicalSO,
  title={Apical secretion of hepatitis B surface antigen from transfected Madin-Darby canine kidney cells.},
  author={Agust{\'i}n Gonz{\'a}lez and S M Nicovani and F Juica},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 9},
  pages={6662-7}
}
Hepatitis B surface antigen (HBsAg), the major envelope component of human hepatitis B virus, during infection drives the assembly and basolateral secretion from hepatocytes of both virions and subviral lipoprotein particles into the bloodstream. We studied the sorting behavior of HBsAg in the heterologous epithelial Madin-Darby canine kidney cells permanently transformed with the hepatitis B virus S gene. These cells, forming tightly packed monolayers in permeable supports, secreted HBsAg… CONTINUE READING