Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking.

Abstract

Wnts are glycosylated proteins secreted from various cell types including mesenchymal, hematopoietic and epithelial cells. Directional secretion of Wnts in polarized epithelial cells is unique; Wnt11 is secreted apically, whereas Wnt5a and Wnt3a are secreted basolaterally. Here, we found that Wnt1 is equivalently secreted both apically and basolaterally in… (More)
DOI: 10.1093/jb/mvx035

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